Modelling Diarrheal Disease Burden + Vaccine Cost-effectiveness Worldwide
Worldwide, diarrheal diseases—which are largely preventable—are a leading cause of mortality for children under five years old. This is usually a result of poor access to clean water, adequate sanitation, and nutrition. In addition to interventions, targeted vaccination of the most vulnerable children may improve their survival and quality of life.
Spatial Epidemiology of Bacterial Zoonoses
Anthrax, caused by Bacillus anthracis, is an acute disease affecting wildlife, livestock, and humans worldwide, although its impact on these populations is underappreciated. Characterizing the spatial distribution of anthrax and assessing wildlife exposure to this pathogen can help produce more accurate assessments of human risk in the environments in which it persists.
Madariaga Virus Emergence in Panamá
Madariaga virus recently emerged as a human disease in Panamá. Previously unknown to cause disease in humans, in 2010 several children experienced grave neurological symptoms and even death as a result of infection by this mosquito-borne virus. To better understand and ideally eventually prevent this disease, it is crucial to identify its natural host and transmission cycles and how human actions affect its spread.
Hantavirus Transmission + Evolution
Hantaviruses are hosted by rodents and insectivores worldwide; some species are transmitted to humans and can cause severe disease. Sin Nombre virus (SNV) and other New World hantaviruses have case fatality rates around 37%–40% and have no vaccine or cure. Understanding the transmission of this family of viruses can help better predict outbreaks and provide insight into other primarily rodent-borne diseases.